Research Progress on Long Non-Coding RNA in Hematological Malignancies--Review.
10.7534/j.issn.1009-2137.2016.01.045
- Author:
Liu-Yan XIN
1
;
Si-Si ZHONG
1
;
Ai-Fei LIU
1
;
Yi-Jian CHEN
2
Author Information
1. Department of Hematology, The First Affiliated Hospital of Gannan Medical College, Ganzhou 341000, Jiangxi Province, China.
2. Department of Hematology, The First Affiliated Hospital of Gannan Medical College, Ganzhou 341000, Jiangxi Province, China. E-mail: chenyj2005@163.com.
- Publication Type:Journal Article
- MeSH:
Hematologic Neoplasms;
genetics;
Humans;
RNA, Long Noncoding;
genetics
- From:
Journal of Experimental Hematology
2016;24(1):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNA (LncRNA) is defined as a class of transcripts more than 200 nucleotides in length and without the protein-coding function. It has been found for years, however, that little is known about the potential role of LncRNA in humans. But recent studies showed that LncRNA can regulate the coding-gene expression and participate in effects of human body. Accumulating evidence demonstrated that LncRNA are involved in cancer incidence, development and progression.With further exploration on the mechanisms of tumors, the relationship between the long non-coding RNA and hematological malignancies increasingly become a hot research. This review focuses on the mechanisms of LncRNA in hematological malignancies.
