Association between single nucleotide polymorphism of insulin-like growth factor receptor gene and idiopathic short stature.
- Author:
Hui HUANG
1
;
Yu YANG
;
Wei WANG
;
Li YANG
;
Li-Ling XIE
;
Ying WANG
;
Hai-Yan WEI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Child, Preschool; Female; Growth Disorders; genetics; Humans; Male; Polymorphism, Single Nucleotide; Receptor, IGF Type 1; genetics
- From: Chinese Journal of Contemporary Pediatrics 2011;13(12):955-958
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association between single nucleotide polymorphism (SNP) of insulin-like growth factor I receptor (IGF-IR) gene and idiopathic short stature (ISS).
METHODSA total of 804 children with ISS and 575 normal controls were recruited from 2008 to 2011. IGF-IR gene SNP was genotyped using the Snapshot Multiplex System.
RESULTSThe distribution frequency of genotype rs1976667 showed no significant difference between the ISS and the control groups, while that of the allele A of rs1976667 was significantly higher in the ISS group than in the control group (P<0.01).
CONCLUSIONSThe allele A at rs1976667 SNP of IGF-IR gene is a risk factor for ISS.
