Value of anti-neutrophil cytoplasmic antibody in diagnosis of Kawasaki disease.
- Author:
Zhi-Gui JIANG
1
;
Ling LIU
;
Cui-Yan YANG
;
Jie WU
Author Information
- Publication Type:Journal Article
- MeSH: Antibodies, Antineutrophil Cytoplasmic; blood; Child; Child, Preschool; Echocardiography; Female; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; blood; diagnosis
- From: Chinese Journal of Contemporary Pediatrics 2012;14(1):45-47
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the value of anti-neutrophil cytoplasmic antibody (ANCA) in diagnosis of Kawasaki disease (KD).
METHODSSerum ANCA was detected in 30 children with typical Kawasaki disease (TKD) and in 16 with incomplete Kawasaki disease (IKD) in the acute and the recovery phases respectively. Twenty-five healthy children were randomly selected as a control group. An ultrasonic cardiography (UCG) was performed on children with KD in the acute phase.
RESULTSThe mean positive rate of serum ANCA in the acute phase in KD children was 65%, with 69% in IKD children and 63% in TKD children, which were obviously higher than that in the control group (P<0.01). The positive rate of serum ANCA in the recovery phase in KD children was significantly lower than that in the acute phase (33% vs 65%, P<0.05). The positive rate of serum ANCA in the acute phase in children with KD was significantly higher than that detected by UCG (P<0.01). The incidence rate of coronary artery lesions in children with positive ANCA was obviously higher than that in children with negative ANCA (43% vs 13%; P<0.05).
CONCLUSIONSSerum ANCA may be used as a reference index for early diagnosis of KD and secondary coronary artery lesions in children.
