Risk factors and pathogen distribution in premature infants with nosocomial sepsis.
- Author:
Jun WU
1
;
Ben-Qing WU
;
Jin-Jie HUANG
;
Liang LUO
;
Yi TANG
Author Information
- Publication Type:Journal Article
- MeSH: Bacteria; isolation & purification; Birth Weight; Catheterization, Central Venous; adverse effects; Cross Infection; etiology; microbiology; Female; Humans; Infant; Infant, Newborn; Infant, Premature; Logistic Models; Male; Parenteral Nutrition; adverse effects; Retrospective Studies; Risk Factors; Sepsis; etiology; microbiology
- From: Chinese Journal of Contemporary Pediatrics 2012;14(2):93-96
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the main risk factors and pathogen distribution of nosocomial sepsis among premature infants.
METHODSThe clinical data of 3418 hospitalized premature infants from January 2003 to December 2010 were retrospectively analyzed for the risk factors and pathogen distribution of nosocomial sepsis.
RESULTSThe incidence of neonatal nosocomial sepsis was 3.10% (106/3418), and the median age at diagnosis of neonatal nosocomial sepsis was 19 (4-48) days. The major pathogens of the infections among these premature infants included gram-positive bacteria (45.2%), especially coagulase-negative Staphylococcus (24.3%), and gram-negative bacteria (41.7%), especially Klebsiella pneumoniae (25.2%), as well as fungus (13.0%). Logistic regression analysis showed that the main risk factors included low birth weight, retention of central venous catheters, and long duration of parenteral nutrition (OR: 3.765, 3.051, and 2.998, respectively; P<0.05).
CONCLUSIONSLow birth weight, retention of central venous catheters, and long duration of parenteral nutrition are the main risk factors for neonatal nosocomial sepsis, whereas the leading pathogen is Klebsiella pneumoniae.
