Clinical features of drug-induced liver injury in children.
- Author:
Xin-Xin ZHU
1
;
Yu ZHU
;
Chao-Min WAN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Chemical and Drug Induced Liver Injury; diagnosis; epidemiology; Child; Child, Preschool; Female; Humans; Infant; Male; Retrospective Studies
- From: Chinese Journal of Contemporary Pediatrics 2012;14(2):131-133
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical features of drug-induced liver injury in children.
METHODSThe clinical data of the hospitalized children with drug-induced liver injury over 5 years were retrospectively reviewed.
RESULTSOf 641 cases of hospitalized children with liver injury, there were 64 cases (10%) of drug induced liver injury. Hepatocellular injury was the most common type of drug-induced liver injury (81%). The major drugs causing drug-induced liver injury included chemotherapy drugs, antibiotics and anti-tuberculosis drugs. Rash (16%), gastrointestinal reaction (15%), fever (14%) and liver intumescence (12%) were common clinical symptoms. A part of patients with drug-induced liver injury (11%) had no symptoms and signs.
CONCLUSIONSDrug-induced liver injury is one of the common causes of liver damage in hospitalized children. Some children with drug-induced liver injury have no symptoms and signs. Hepatocellular injury is a major type of drug-induced liver injury in children, resulting less severe liver damage.
