Clinicopathological characteristics and prognosis of 11 patients with renal mucinous tubular and spindle cell carcinoma.

Jiwei Huang; Baijun Dong; Jin Zhang; Yonghui Chen; Xiaorong WU; Wen Kong; Di Jin; Wei Xue; Dongming Liu; Yiran Huang

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Clinicopathological characteristics and prognosis of 11 patients with renal mucinous tubular and spindle cell carcinoma.

Author: Jiwei HUANG ¹ ; Baijun DONG ¹ ; Jin ZHANG ¹ ; Yonghui CHEN ¹ ; Xiaorong WU ¹ ; Wen KONG ¹ ; Di JIN ¹ ; Wei XUE ¹ ; Dongming LIU ¹ ; Yiran HUANG ²
Author Information

1. Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
2. Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Email: hyrrenji2@aliyun.com.
Publication Type:Journal Article
MeSH: Adenocarcinoma, Mucinous; Carcinoma; Carcinoma, Renal Cell; diagnosis; Female; Humans; Kidney; Kidney Neoplasms; diagnosis; Male; Neoplasm Recurrence, Local; Nephrectomy; Prognosis; Retrospective Studies; Tomography, X-Ray Computed
From: Chinese Journal of Oncology 2014;36(9):693-696
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the clinicopathological features, treatment and prognosis of renal mucinous tubular and spindle cell carcinoma (MTSCC).
METHODSThe clinicopathological data of eleven patients of pathologically confirmed renal MTSCC were reviewed retrospectively. Among the 11 patients, there were 4 males and 7 females with a mean age of 51.6 years (range, 24 to 81 years). Two patients presented with hematuria, one presented with lumbago and others were asymptomatic.
RESULTSThe renal MTSCC was of hypovascular tumor in enhanced CT scan. Seven cases were treated with radical nephrectomy, and the other four with partial nephrectomy. The mean diameter of tumors was 4.4 cm. The TNM stages were as follows: pT1aN0M0 in 6, pT1bN0M0 in 3, pT2N0M0 in 2 cases. Histological examination of the tumors showed that they consisted of spindle cells arranged in tubular and trabecular patterns embedded in a myxoid stroma. No recurrence or metastasis was observed during the follow-up (median 41 months).
CONCLUSIONSMTSCC is a rare low-grade renal epithelial carcinoma with a relatively good prognosis. Preoperative CT scan is partly helpful for diagnosis and guiding decision making. Nephron-sparing surgery is recommended in most cases, especially in patients with small tumors.