l-myc Polymorphism in Gastric Cancer, Lung Cancer, and Hepatocellular Carcinoma.
- Author:
Min Su PARK
1
;
Sae Bin JUNG
;
Yeon Hee PARK
;
Bong Seog KIM
;
Hyun Ju PARK
;
Hee Jae LEE
;
Soon Ae KIM
;
Bong Keun CHOE
;
Joo Ho CHUNG
Author Information
1. Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Korea. jhchung@ khu.ac.kr
- Publication Type:Original Article
- Keywords:
Gastric neoplasm;
Lung neoplasm;
Hepatocellular carcinoma;
l-myc polymorphism
- MeSH:
Carcinoma, Hepatocellular*;
Digestion;
DNA;
Gene Frequency;
Genotype;
Humans;
Lung Neoplasms*;
Lung*;
Oncogenes;
Polymerase Chain Reaction;
Stomach;
Stomach Neoplasms*
- From:Cancer Research and Treatment
2002;34(6):436-438
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study was performed to see if a particular polymorphism in the l-myc, a nuclear oncogene at the 1p32 locus, might be associated with greater risk of gastric cancer, lung cancer and hepatocellular carcinomas (HCC) in Korean patients. MATERIALS AND METHODS: Genomic DNA, derived from patients diagnosed with gastric cancer (n=57), lung cancer (n=39), HCC (n=35) and healthy individuals (n= 176), was examined. The l-myc polymorphism under study was visualized by PCR followed by EcoRI digestion. RESULTS: There was no significant difference in the distribution of the l-myc polymorphism genotypes and allele frequencies between the cancer patients and the controls. CONCLUSION: The l-myc polymorphism does not appear to be indicative of elevated risk of cancers of the stomach, lung and HCC.
