Impact of acute smoking on artery function in healthy chronic smokers
10.3760/cma.j.issn.0253-3758.2011.05.007
- VernacularTitle:外周动脉张力测定健康慢性吸烟者吸烟后血管功能急性改变
- Author:
Chao XUE
1
;
Yi-Hong SUN
;
Rong-Jing DING
;
Yuan-Yuan FU
;
Da-Yi HU
Author Information
1. 北京大学人民医院
- Keywords:
Smoking;
Endothelium;
Compliance;
Cell adhesion molecules: Tissue plasminogen activator
- From:
Chinese Journal of Cardiology
2011;39(5):410-413
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To explore the effect of acute smoking on vascular endothelial function,anerial stiffness and the possible underlying mechanisms. Methods We measured the endothelial function and arterial stiffness in 50 healthy chronic smokers before and after acute smoking with EndoPAT2000.The test was carried out on two separate finger tips.The endothelial function was evaluated by PAT ratio of the tinger tip and systemic arterial stiffness was evaluated by augmentation index(AI).Plasma soluble intercellular adhesion molecule-1(sICAM-1)and tissue plasminogen activator(tPA)before and 20 min after acute smoking were measured with enzyme linked immuno sorbent assay.Results The PAT ratio was decreased(1.87±0.40 VS. 1.73±0.28,P=0.004)while AI was significantly increased after acute smoking(2.94%±21.77%vs.7.11%±20.65%,P=0.01).There was no significant changes in sICAM[(306.5±76.1)μg/L vs.(315.7±90.9)μg/L,P=0.402],but tPA[7.87(5.41-10.08)μg/L vs.could acutely affect endothelia function,arterial stiffness and deteriorate the activity of fibrinolvtic system which could lead to coronary thrombosis in smokers.
