Tacrolimus ointment: An Open study for Effects on Severe Facial Atopic Dermatitis in Korean.
10.5021/ad.2002.14.4.195
- Author:
Won Woo CHOI
;
Pan Gyo SEO
;
Kyu Han KIM
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
Tacrolimus
- MeSH:
Burns;
Dermatitis, Atopic*;
Follow-Up Studies;
Humans;
Research Personnel;
Tacrolimus*
- From:Annals of Dermatology
2002;14(4):195-199
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: In recent studies, tacrolimus ointment has been shown to be effective for the treatment of atopic dermatitis with an excellent safety profile. OBJECTIVE: This study was done to assess the efficacy and side-effects of tacrolimus ointment for the facial atopic dermatitis(AD) in Korean. PATIENTS AND METHODS: Open-label, non-comparative study with 2 months' follow-up was done to assess the efficacy and safety of tacrolimus ointment (Protopic0ointment 0.1%, Fujisawa, Japan) in moderate to severe facial AD. Patients were instructed to apply it two times daily for 8 weeks. Facial lesions were evaluated at baseline, 4 and 8 weeks of treatment with in-tensity score by investigator. RESULTS: In comparing of intensity scores and each clinical score at baseline with those of 4 and 8 weeks of treatment, a significant decrease was noticed at all follow-up periods. Burning sense(54.5%) and pruritus(18.2%) were detected. CONCLUSION: Tacrolimus ointment is effective in treatment of severe facial AD and has tolerable mild adverse effects at the site of application in Korean.
