Effect of different combined antihypertensive regimen on the erectile function in malehypertensive patients
10.3760/cma.j.issn.0253-3758.2011.07.008
- VernacularTitle:厄贝沙坦与美托洛尔的联合方案对男性高血压患者性功能的影响
- Author:
Long-Quan YANG
1
;
Jing YU
;
Rui-Xin MA
;
Pei-Jun LIU
;
Xue-Ya GUO
;
Xiu-Li LI
;
Peng CHANG
;
Hao HU
;
Feng ZHAO
;
Feng BAI
Author Information
1. 兰州大学第二医院
- Keywords:
Hypertension;
Sex disorders;
Drug therapy
- From:
Chinese Journal of Cardiology
2011;39(7):636-641
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of felodipine combined irbesartan regimen with that of felodipine combined metoprolol regimen on the sexual function in male hypertensive patients. Method One handred and twenty-three male hypertensive paitients (age 25 to 60) were randomly assigned to felodipine (5 mg/d) plus irbesartan ( 150 mg/d, n=64) group and felodipine (5 mg/d) plus metoprolol (47.5 mg/d, n=59) group. Dosage of felodipine were doubled after 4 weeks if the blood pressure were ≥140/ 90 mm Hg (1 mm Hg=0.133 kPa). At the baseline and post 24th week treatment, sexual function of patients was assessed by the International Index of Erectile Function (IIEF) Questionaire. Serum testosterone (T), sex hormone binding globulin (SHBG), 4-hydroxynonenal (HNE), 8-hydroxy-2′-deoxyguanosine (8-OHdG) and Malonaldehyde (MDA) were measured by Radioimmunoassay (RIA), ELISA and TBA respectively. Results Total prevalence of erectile dysfunction (ED),T, SHBG and HNE were similar between pre- and post-treatment in two groups (P>0.05). On the other hand, the scores of the mild ED and sexual desire (SD) were improved and both serum 8-OHdG and MDA in patients with ED decreased [(146.02±60.54)ng/L vs. (139.89±62.03)ng/L, P=0.048 and (6.59±1.75)μmol/L vs. (5.51±1.65)μmol/L,P=0.039] in Felodipine plus Irbesartan group. Conclusion The results suggested that Felodipine + Irbesartan regimen may be superior to Felodipine + metoprolol regimen for male hypertensive patients with mild ED.
