A Case of Glomeruloid Hemangioma in a Patient with Multicentric Castleman's Disease.
10.5021/ad.2002.14.4.220
- Author:
Nark Kyoung RHO
;
Sang Jin PARK
;
Dong Youn LEE
;
Eil Soo LEE
- Publication Type:Case Report
- Keywords:
Glomeruloid hemangioma;
Castleman's disease
- MeSH:
Adult;
Capillaries;
Cytoplasm;
Endothelial Cells;
Eosinophils;
Female;
Giant Lymph Node Hyperplasia*;
Hemangioma*;
Humans;
POEMS Syndrome;
Skin;
von Willebrand Factor
- From:Annals of Dermatology
2002;14(4):220-225
- CountryRepublic of Korea
- Language:English
-
Abstract:
Glomeruloid hemangioma is a histologically distinctive cutaneous angioma which is rarely de-scribed in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome and multicentric Castleman's disease. We report an additional case of glomeruloid hemangioma in a 30-year-old Korean woman with multicentric Castleman's disease showing features of POEMS syndrome. Histopathology revealed multiple dermal dilated vascular spaces composed of a conglomerate of capillaries, resulting in structures reminiscent of renal glomeruli. Periodic acid-Schiff-positive and diastase-resistant eosinophilic globules were found within the cytoplasm of vacuolated endothelial cells. The endothelial cells lining the capillary loops showed positive immunostaining for factor VIII-related antigen and CD31.
