Efficacy and safety of the HAA regimen as induction chemotherapy in 236 de novo acute myeloid leukemia.
- VernacularTitle:HAA方案诱导治疗成人初发急性髓系白血病236例疗效观察
- Author:
Pei-pei YE
1
;
Qi-tian MU
;
Fei-fei CHEN
;
Wen-yuan MAI
;
Hai-tao MENG
;
Wen-bin QIAN
;
Hong-yan TONG
;
Jian HUANG
;
Yin TONG
;
Zhi-mei CHEN
;
Ji-yu LOU
;
Yun-gui WANG
;
Wan-mao NI
;
Jie JIN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; adverse effects; therapeutic use; Female; Humans; Leukemia, Myeloid, Acute; drug therapy; Male; Middle Aged; Retrospective Studies; Young Adult
- From: Chinese Journal of Hematology 2013;34(10):825-829
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy and safety of the HAA regimen (homoharringtonine, cytarabine and aclarubicin) as induction chemotherapy in de novo acute myeloid leukemia (AML).
METHODSThe efficacy and safety of 236 de novo AML patients who received the HAA regimen as induction chemotherapy were retrospectively analyzed. The complete remission (CR) rate was assayed. Kaplan-Meier method was used to estimate overall survival (OS) and relapse free survival (RFS), and the differences were compared by Log-rank test.
RESULTSThe overall CR rate was 78.0%, and 65.7% of the patients attained CR in the first induction cycle. The early death rate was 4.7%. The median followup time was 41(1-161) months. The estimated 5-year OS and 5-year RFS rates were 44.9% and 45.5%, respectively. The CR rates of patients with favorable, intermediate and unfavorable cytogenetics were 92.9%,78.6%and 41.7%, respectively. The 5-year OS of favorable and intermediate group were 61.1% and 45.1%, respectively. The 5- year RFS of favorable and intermediate group were 49.0% and 45.4%, respectively. The median survival time of unfavorable group was only 5 months. The side effects associated with the HAA regimen were tolerable, in which the most common toxicities were myelosuppression and infection.
CONCLUSIONThe HAA regimen is associated with a higher rate of CR and longer survival time and its toxicity could be tolerated.