- VernacularTitle:中国T幼淋巴细胞白血病临床及实验室特征
- Author:
Yan-ru ZHANG
1
;
Jun-yuan QI
;
Hui-min LIU
;
Wei LIU
;
Wen-yang HUANG
;
Shu-hui DENG
;
Shu-hua YI
;
Yan XU
;
Zeng-jun LI
;
Ming-wei FU
;
De-hui ZOU
;
Yao-zhong ZHAO
;
Lu-gui QIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Bone Marrow Examination; China; Female; Humans; Leukemia, Prolymphocytic, T-Cell; diagnosis; Male; Middle Aged; Retrospective Studies; Young Adult
- From: Chinese Journal of Hematology 2013;34(10):839-843
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical and laboratory characteristics and survival of Chinese patients with T- cell prolymphocytic leukemia (T-PLL).
METHODSEleven patients with T-PLL admitted in our hospital from Jan 2006 to Oct 2012 were retrospectively analyzed.
RESULTSOf the 11 patients, nine were males and two females, with the median age of 56.0(19-69) years old. All the patients, except for three, presented with leukocytosis. The incidence of hyperleukocytosis (1/11) was less frequent than that in the British series (75%) (P=0.000). Lymphocyte counts in peripheral blood were increased in 9 of the 11 patients with the median absolute lymphocyte count (ALC) of 17.22(0.58-148.83)×10⁹/L. Superficial lymphadenopathy and splenomegaly were the most common physical signs. It was common that serum lactate dehydrogenase (LDH) and beta 2 microglobulin(β2-MG)were higher than normal level. All cases were positive for CD2/CD3/CD5/TCRαβ, negative for CD1a /HLA-DR and TdT, and most of them were strong positive for CD7 expression. By chromosome analyses, most cases. (9/10) have normal chromosome. This rate is significantly higher than that of the British and American series (3% and 25%, respectively) (P=0.000, P=0.001). The 14q11 abnormality and trisomy 8q, which are common among Western cases, were not observed in any of our cases. With a median follow-up of 23.0 months, three patients died. Two year progress free survival (PFS) and overall survival (OS) were 53.3% and 50%, respectively. There were 3 patients with PFS over a number of years, whether it should be considered as the T-chronic lymphocytic leukemia (T-CLL) is worthy of further studies.
CONCLUSIONThe common clinical manifestations of T-PLL patients were increased lymphocyte counts and lymphadenopathy as well as splenomegaly. And most cases have high level of blood LDH and β2- MG and normal chromosome karyotype.