Effect of handportable mobiletelephone microwave radiation on rat central neuron apoptosis.
- Author:
Wei-guo LIU
1
;
Xiao-feng YANG
;
Yong-jian ZHU
;
Hong SHEN
;
Xiu-yi JIANG
;
Shi-ting LU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; radiation effects; Brain; pathology; radiation effects; In Situ Nick-End Labeling; Male; Microwaves; adverse effects; Neurons; pathology; radiation effects; Proto-Oncogene Proteins; analysis; Proto-Oncogene Proteins c-bcl-2; analysis; Rats; Rats, Sprague-Dawley; bcl-2-Associated X Protein
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2003;21(1):45-47
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of handportable mobiletelephone microwave radiation on rat central nervous system by setting up rat model.
METHODS80 healthy male SD rats (weighed about 200 g) were divided into 4 groups at random: control, radiation, decranium, decranium + radiation. TUNEL method was adopted used to detect the apoptosis of neurons after irradiation, then immunohistochemistry was used to detect Bcl-2, Bax expression in all brain tissue.
RESULTSTUNEL positive rate, Bax and Bcl-2 positive cell numbers could be found in decranium + radiation group [(26.45 +/- 9.27)%, (23.5 +/- 3.58), (11.1 +/- 2.55) respectively]. There were significant differences among control [(9.59 +/- 2.55)%, 14.2 +/- 2.46, 7.0 +/- 1.14 respectively], decranium group [(9.52 +/- 1.93)%, 15.5 +/- 1.77, 7.4 +/- 1.76], radiation group [(10.04 +/- 3.62)%, 15.9 +/- 2.02, 7.2 +/- 1.07] (P < 0.01). But the difference was not found in the ratio of Bax to Bcl-2.
CONCLUSIONMicrowave radiation did not affect the intact rat, but did promote the occurrence of neuron apoptosis in cranial defect rat. Bax, Bcl-2 gene participated in regulation of apoptosis. The intact cranium may be an important factor to protect the neurons against handportable mobiletelephone microwave radiation to some extent.
