Comparison of TGF-beta1 expression of lung cancer in Gejiu miners with that in non-miners in other regions.
- Author:
Ping JIANG
1
;
Ke-wei JIN
;
Qian GAO
Author Information
- Publication Type:Journal Article
- MeSH: Humans; Immunohistochemistry; In Situ Hybridization; Lung Neoplasms; genetics; metabolism; pathology; RNA, Messenger; genetics; metabolism; Transforming Growth Factor beta; genetics; immunology; Transforming Growth Factor beta1
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(1):36-38
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the different expression of transforming growth factor beta(1) (TGF-beta(1)) in lung cancer specimens of Gejiu miners, and non-miners in other regions.
METHODSThirty specimens of Gejiu miners' lung cancer and 30 specimens of non-miners' were observed in this experiment. The expression of TGF-beta(1) protein and TGF-beta(1) mRNA were detected by the methods of immunohistochemistry and in situ hybridization. The results were quantitatively analyzed using image analysis system.
RESULTSThe positive rate of TGF-beta(1) protein expression in Gejiu miners and non-miners was 75.39%and 44.78% respectively, and the positive rate of TGF-beta(1) mRNA was 63.96% and 34.07% respectively. There were significant differences between the two groups (P < 0.01).
CONCLUSIONThe expression of TGF-beta(1) in lung cancer of Gejiu miners was significantly higher than that of non-miners. The pathogenesis of lung cancer may be different between Gejiu miner and non-miners. High expression of TGF-beta(1) may be one of the reasons of high incidence of lung cancer in Gejiu miners.
