Relationship of genetic polymorphism of microsomal epoxide hydrolase with susceptibility of chronic benzene poisoning.
- Author:
Zhong-bin ZHANG
1
;
Shou-yong GU
;
Jun-xiang WAN
;
Xi-peng JIN
;
Zhao-lin XIA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Benzene; metabolism; poisoning; Case-Control Studies; Epoxide Hydrolases; genetics; Female; Genetic Predisposition to Disease; Humans; Life Style; Male; Middle Aged; Occupational Diseases; genetics; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(3):176-180
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between genetic polymorphisms of microsomal epoxide hydrolase (mEH) and susceptibility of chronic benzene poisoning (BP).
METHODA case-control study was conducted. 152 BP patients and 152 workers occupationally exposed to benzene without poisoning manifestations were investigated. Polymerase chain reaction-restrained fragment length polymorphism technique (PCR-RFLP) was applied to detect the single nucleotide polymorphisms (SNPs) on c.113 and c.139 of mEH gene.
RESULTSThe risk of BP for individuals carrying mEHc.113 C/C genotype was 0.60 (OR = 0.60, 95% CI: 0.37 - 0.97, P = 0.04) of those carrying T/T and T/C genotypes. In non-smoking population, the risk of BP for subjects carrying mEHc.113 C/C genotype was 0.56 (OR = 0.56, 95% CI: 0.33 - 0.96, P = 0.03) of those carrying T/T and T/C genotypes, and in non-drinking population, the individuals carrying mEHc.113 C/C genotype was 0.51 (OR = 0.51, 95% CI: 0.30 - 0.86, P = 0.01) of those carrying T/T and T/C genotypes.
CONCLUSIONThe subjects carrying mEHc.113 C/C genotype and together with non-smoking or non-drinking habit may have lower risk of chronic benaene poisoning.
