Effect of taurine on NOS activity in hippocampus of rat exposed lead.
- Author:
Feng YANG
1
;
Ji-sheng LI
;
Pei YAN
;
Ya-hua LIU
;
Da-ning WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Hippocampus; enzymology; Lead; toxicity; Learning; drug effects; Long-Term Potentiation; drug effects; Male; Memory; drug effects; Memory Disorders; chemically induced; enzymology; Neurons; enzymology; Neuroprotective Agents; pharmacology; Nitric Oxide Synthase; metabolism; Rats; Rats, Wistar; Taurine; pharmacology
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(3):203-206
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of taurine on lead-induced damage to the ability of learning and memory.
METHODSUsing NADPH-d histochemistry method to study the change of rat NOS positive neurons in hippocampus. Rats in experimental groups were fed with different doses of lead in drinking water (0.011, 0.110 g/L), and different doses of taurine (5, 10 g/kg).
RESULTSTaurine (10 g/kg) could increase the number of NOS positive neurons in CA1 and dentate gyrus subregion in hippocampus of rats exposed to lead. The number of NADPH-d positive neurons in CA1 and dentate gyrus subregion for low lead (0.011 g/L) and high taurine (10 g/kg) group (51.80 +/- 4.68, 47.40 +/- 4.20, respectively) were higher than those in the low lead (0.011 g/L) group (41.20 +/- 5.32, 39.87 +/- 3.81, respectively, P < 0.05).
CONCLUSIONTaurine may antagonize lead-induced damage to the ability of learning and memory.
