Clinical features and changes in liver enzymes AST and ALT on the patients with beta-lactam antibiotic allergy
- Author:
Doan Quang Phan
- Publication Type:Journal Article
- Keywords:
drug allergy
- MeSH:
Drug Hypersensitivity;
Anti-Bacterial Agents;
beta-Lactams;
diagnosis
- From:Journal of Practical Medicine
2002;435(11):12-15
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The study involved two groups: case group involved 65 patients with beta-lactam antibiotic allergy who were treating at B¹ch Mai Hospital during year 2000 and 25 healthy people were used a control group. Main findings: allergic symptoms onset rapidly within first 30 minutes in 43.07% of patients, onset after 1 hour of drug administration in 16.92% and after 1 day in 9.22%. 52.3% of patients have individual history and 13.84% have family history of allergy. Whole-body erythema occurred on 48.07% of patients, urticaria and Quinck edema on 27.69%, Stevens-Johnson syndrome on 18.46%, anaphylactic shock on 61.5% and drug-caused hepatitis on 4.61%. Levels of liver enzymes AST and ALT increase significantly in comparison with control group.
