Investigation on NB4 cell responses to realgar by cDNA microarray.
- Author:
Huai-yu WANG
1
;
Shan-xi LIU
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; pharmacology; Arsenicals; pharmacology; Gene Expression Profiling; Gene Expression Regulation; drug effects; Genes, Neoplasm; genetics; Humans; Leukemia, Promyelocytic, Acute; genetics; pathology; Materia Medica; pharmacology; Oligonucleotide Array Sequence Analysis; Sulfides; pharmacology; Tumor Cells, Cultured
- From: China Journal of Chinese Materia Medica 2002;27(8):600-604
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo elucidate the molecular mechanism of realgar-induced apoptosis and differentiation of acute promyelocytic leukemia(APL) cell line NB4.
METHODThe response of NB4 cells to realgar was explored with a cDNA microarray representing 1003 different human genes.
RESULTThe analysis of gene expression profiles indicated that 9 genes were up-regulated and 37 genes were down-regulated. Among the 9 up-regulated genes, 2 genes were involved in proteasome degradation pathway.
CONCLUSIONPSMC2, PSMD1 and ITGB1 genes may play a role in the apoptosis and differentiation of NB4 cells.
