Effect of dan-shen, san-qi of different proportion on platelet aggregation and adhesion in normal rabbits.
- Author:
Ting LIU
1
;
Cai-ling QIN
;
Yi ZHANG
;
Li-yuan KANG
;
You-fu SUN
;
Bo-li ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Male; Panax; chemistry; Plant Roots; chemistry; Plants, Medicinal; chemistry; Platelet Adhesiveness; drug effects; Platelet Aggregation; drug effects; Platelet Aggregation Inhibitors; pharmacology; Rabbits; Salvia miltiorrhiza; chemistry
- From: China Journal of Chinese Materia Medica 2002;27(8):609-611
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of the crude extracts of Dan-shen root and San-qi of different proportion on platelet aggregation and adhesion in normal rabbits.
METHODWith rabbits, ig. (4d, exsanguinated via carotid artery, percentage of platelet aggregation and adhesion was measured.
RESULT AND CONCLUSIONAspirin (4.4 mg/Kg) could markedly inhibit platelet aggregation and adhesion in normal rabbit. The proportions of Dan-shen root/San-qi (10:0, 10:1, 10:3, 10:6, 1:10) could markedly inhibit platelet aggregation, among which 10:3 was the best. San-qi alone had little effect on aggregation. The proportions of Dan-shen root/San-qi (10:3, 10:6, 0:10) could markedly inhibit platelet adhesion, among which 0:10 was the best, and the proportions(10:0, 10:1, 1:10) had little effect.
