Study on improvement of dissolution rate of water-honeyed pills of six herbs with rehmunnia by technique of super fine crushing.
- Author:
Rui-qiang SU
1
;
Yu HE
;
Rui-cheng WANG
;
Lian-hua ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Acetophenones; analysis; chemistry; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; Particle Size; Plants, Medicinal; chemistry; Quality Control; Rehmannia; chemistry; Solubility; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2002;27(7):511-513
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the affection of crushing technology on quality. The dissolution of Pills of Six Herbs with Rehmunnia prepared by different crushing technology was determined by taking the dissolution of Paeonol as test marker.
METHODThe Pills was prepared with the fine powder which was crushed by normal crusher or super fine crusher. The rotatory-basket method was used, and the cumulative dissolution percentage was determined by UV.
RESULTStatistics indicated there was a significant difference in dissolution parameter (T50) between super fine crushing powder Pills and normal fine-crushing powder Pills (P < 0.01), and there was a difference in dissolution of different batches of Pills of Six Herbs with Rehmunnia prepared by the normal crush technique (P < 0.05).
CONCLUSIONThe determination of dissolution of Pills of Six Herbs with Rehmunnia is necessary. In order to improve the quality of drugs, we should adopt the technique of super fine crushing in the preparation procedure.
