Effect of zishuijianghuoyin on expression of lymphocyte AngII receptor (AT-1) mRNA of experimental hypertension rats.
- Author:
Sheng-bao LIAO
1
;
Rong-guang DING
;
Li-li DING
;
Guang-wei LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Hypertension, Renovascular; metabolism; Lymphocytes; metabolism; Male; Plants, Medicinal; chemistry; RNA, Messenger; genetics; Rats; Rats, Wistar; Receptors, Angiotensin; biosynthesis; genetics
- From: China Journal of Chinese Materia Medica 2002;27(7):531-534
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the immuno-neurologic regulation of hypertension and its inherent law as well as the mechanisms of curing and systemic regulating effect of ZiShuiJiangHuoYin(ZSJHY).
METHODTo detect expression level of AT-1mRNA in two-kidney-one-clamp renal hypertension rat lymphocyte cell by means of RT-PCR.
RESULTThe level of AT-1 mRNA in lymphocyte was higher in group of 2K1C-RHR than that in normal group. ZSJHY (20 g/kg, 40 g/kg) had regulating effect on this.
CONCLUSIONDepressing excessive expression of lymphocyte AT-1 mRNA may be one of the mechanisms where ZSJHY exert immunoregulation action.
