Mechanical research on effects of yishenqing on membranous nephropathy.

Author: Yan SONG ¹ ; Jian MA ; Chang-ling LI
Author Information

1. Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Science, Peking University 100083, Beijing, China.
Publication Type:Journal Article
MeSH: Animals; Diuretics; pharmacology; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Glomerulonephritis, Membranous; drug therapy; immunology; pathology; Lymphocyte Activation; drug effects; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phytotherapy; Plants, Medicinal; chemistry; Rabbits; Rats; Rats, Wistar
From: China Journal of Chinese Materia Medica 2002;27(7):537-540
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the therapeutic effect and mechanism of Yishenqing on rabbit membranous nephropathy.
METHODThe rabbit membranous nephropathy model was induced by cationic bovine serum albumin, and the immunity of mice together with urine volume and haemorheological property of rats were also estimated.
RESULTYishenqing could significantly reduce the urinary protein content, preserve the renal function and pathologically restore the glomeruli. Moreover, its effects also include immunity enhancement, diuretic property and blood stasis amelioration.
CONCLUSIONYishenqing has good effects on the rabbit membranous nephropathy, which is probably due to the effects of diuretic property, immunity enhancement and blood stasis amelioration.