Changes of dehydroandrographolide's contents of andrographis tablet in the process of production.
- Author:
Xiao-dan HUANG
1
;
Zi-ren SU
;
Xiao-ping LAI
;
Shu-hai LIN
;
Xiao-bing DONG
;
Zhong-qiu LIU
;
Pei-shan XIE
Author Information
- Publication Type:Journal Article
- MeSH: Andrographis; chemistry; Diterpenes; analysis; Drug Stability; Drugs, Chinese Herbal; administration & dosage; chemistry; isolation & purification; Hot Temperature; Plant Components, Aerial; chemistry; Plants, Medicinal; chemistry; Tablets; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2002;27(12):911-913
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo recognize changes in the contents of ingredients of Andrographis Tablet in the process of production.
METHODAdopting TLCS, TLC, HPLC to detect effective contents of ingredients which are produced in every stage of process of Andrographis Table's production.
RESULTHandling with the fresh Herba Andrographis according to current pharmacopeoia's technology, it showed that only dehyandrographolide can be detected. It indicated that the main factor that leads to chemical change is the heating process in the process of production.
CONCLUSIONAvoiding heating treatment or reducing heating treatment time is the main factor to protect the effective ingredients.
