A study on the percutaneous penetration of artesunate from various reservoir vehicles.
- Author:
Li-ling ZHOU
1
;
Hai-xia HOU
;
Rui LI
Author Information
- Publication Type:Journal Article
- MeSH: 2-Propanol; pharmacology; Administration, Cutaneous; Animals; Antimalarials; administration & dosage; pharmacokinetics; Artemisinins; administration & dosage; pharmacokinetics; Drug Carriers; Drug Delivery Systems; Hydrogen-Ion Concentration; Mice; Mice, Inbred BALB C; Mice, Nude; Sesquiterpenes; administration & dosage; pharmacokinetics; Skin Absorption; drug effects
- From: China Journal of Chinese Materia Medica 2002;27(9):662-665
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the main factors which affect the percutaneous penetration of artesunate and provide efficient data for the artesunate transdermal delivery system.
METHODTransdermal speed constant and accumulative amount of 12 hours were used for the estimations of various reservior vehicles, and the supplement orthodox design was used to study the effect of pH, various proportion of IPA/Water/IPM, and drug concentration.
RESULTDrug concentration and pH were the main factors which affected the percutaneous penetration of artesunate.
CONCLUSIONThe suitable reservior vehicle can prompt the percutaneous penetration of artesunate, and artesunate TTS will be made with further studies.
