Experimental studies of hypoglycemic action on total flavone of Ampelopsis grossedentata from Guangxi.
- Author:
Zheng-xian ZHONG
1
;
Jie-pin QIN
;
Gui-fen ZHOU
;
Xue-fen CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Ampelopsis; chemistry; Animals; Blood Glucose; metabolism; China; Diabetes Mellitus, Experimental; blood; Drugs, Chinese Herbal; isolation & purification; pharmacology; Epinephrine; antagonists & inhibitors; Female; Flavonoids; isolation & purification; pharmacology; Glucose; antagonists & inhibitors; Hypoglycemic Agents; isolation & purification; pharmacology; Mice; Plant Leaves; chemistry; Plant Stems; chemistry; Plants, Medicinal; chemistry
- From: China Journal of Chinese Materia Medica 2002;27(9):687-689
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study hypoglycemic action of total flavone (GXTF) of Ampelopsis grossedentata from Guangxi by observing the effects of GXTF on blood glucose levels in many strain animal models.
METHODThe blood glucose levels in many strain animal models were determined after oral administration, with the models of diabetes induced by alloxan, of hyperglycemic mice induced by epinephrine and glucose, and normal mice.
RESULTGXTF had better therapeutical action on diabetes mice induced by alloxan, and could significantly lowered the blood glucose levels of hyperglycemic mice induced by epinephrine and glucose, but had no significant effects on blood glucose levels of normal mice. Acute toxicity test showed that the maximum oral dosage is 26.0 g.kg-1.
CONCLUSIONGXTF has better hypoglycemic effect on many strain animal models and toxicity is vary small.
