Effect of essential oil of Radix Angelicae Dahuricae on beta-endorphin, ACTH, NO and proopiomelanocortin of pain model rats.
- Author:
Hong NIE
1
;
Ying-jun SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adrenocorticotropic Hormone; blood; Analgesics; isolation & purification; pharmacology; Angelica; chemistry; Animals; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Formaldehyde; Hypothalamus; metabolism; Male; Nitric Oxide; metabolism; Oils, Volatile; isolation & purification; pharmacology; Pain; chemically induced; metabolism; Plant Roots; chemistry; Plants, Medicinal; chemistry; Pro-Opiomelanocortin; biosynthesis; genetics; RNA, Messenger; genetics; Rats; Rats, Sprague-Dawley; beta-Endorphin; metabolism
- From: China Journal of Chinese Materia Medica 2002;27(9):690-693
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of essential oil of Radix Aangelicae Dahuricae (EOAD) on beta-endorphin Adrenocorticotropic hormone(ACTH), Nitric oxide (NO) and Proopiomelanocortin (POMC) of pain model rats induced by formaldehyde.
METHODbeta-endorphin and ACTH were detected with radio-immunity, the amount of masculine cell expression of Proopiomelanocortin mRNA in hypothalamus, and brainstem of pain model was detected with in situ hybridization and NO with chemical method.
RESULTEOAD could increase beta-endorphin, NO and the amount of masculine cell expression of Proopiomelanocortin mRNA significantly in hypothalamus and brainstem of rats.
CONCLUSIONEOAD which may be central analgesic, is associated with endogenous opiate-like substance such as POMC and beta-endorphin.
