Application of beta-cyclodextrin inclusion technique in new dosage form of angelica sinensis essential oil.
- Author:
Chang-xin ZHOU
1
;
Jian-kai ZOU
;
Yu ZHAO
;
Yao-zu CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Angelica sinensis; chemistry; Cyclodextrins; Dosage Forms; Drug Carriers; Drug Stability; Oils, Volatile; administration & dosage; analysis; isolation & purification; Plant Roots; chemistry; Plants, Medicinal; chemistry; Solubility; Technology, Pharmaceutical; methods; X-Ray Diffraction; beta-Cyclodextrins
- From: China Journal of Chinese Materia Medica 2002;27(11):832-845
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo make a solid form of Angelica Sinensis essential oil by preparing its inclusion compound with beta-cyclodextrin and evaluate the inclusion rate, dissolution rate and liberating rate of this complex.
METHODGC-MS, X-ray diffraction and thin-layer chromatography were applied to characterize the essential oil and the inclusion compound.
RESULTThe inclusion compound was shown to form a new phase by X-ray diffraction analysis. GC-MS and TLC check-up corroborated the composition of the free oil and the inclusion oil remaining the same.
CONCLUSIONThe results showed Angelica Sinensis essential oil was more stable with beta-cyclodextrin inclusion. The preparation of this inclusion compound has advantages in limited amount, long time effect, easily preserved and convenient administration as a new dosage form.
