Study on the preparation of venenum bufonis beta-cyclodextrin inclusion complexes.
- Author:
Tao GUO
1
;
Hong-tao SONG
;
Ming-hong ZHAO
;
Ru-hua ZHANG
;
Xian LI
Author Information
- Publication Type:Journal Article
- MeSH: Amphibian Venoms; administration & dosage; chemistry; Animals; Bufanolides; Bufo bufo; Cholenes; analysis; Cyclodextrins; Drug Carriers; Drug Stability; Materia Medica; administration & dosage; chemistry; Solubility; Technology, Pharmaceutical; methods; beta-Cyclodextrins
- From: China Journal of Chinese Materia Medica 2002;27(11):835-837
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.
METHODAn optimal condition was established by the uniform design. Under the optimal conditions the Venenum Bufonis beta-cyclodextrin inclusion complexes were prepared with 5 different methods.
RESULTThe ball grinding method was superior to other four methods. The bufadienolide inclusion rate of Venenum Bufonis beta-cyclodextrin prepared with ball grinding method was 85.42%.
CONCLUSIONBall grinding method is the best method for the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.
