Effect of the composition and structure of the drug delivery device on the drug release rate.
- Author:
Qin LIU
1
;
Li TANG
;
Ning DING
;
Chao YANG
;
Aiguo WANG
Author Information
1. Medical College, Dalian University, Dalian 116622, China.
- Publication Type:Journal Article
- MeSH:
Delayed-Action Preparations;
chemistry;
Drug Carriers;
administration & dosage;
chemistry;
Drug Delivery Systems;
Estradiol;
administration & dosage;
Progesterone Congeners;
administration & dosage;
Silicones;
Testosterone;
administration & dosage
- From:
Journal of Biomedical Engineering
2012;29(2):296-300
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of the property of drugs and the structure of drug delivery devices on the drug release rate, the effects of sealing methods, length, thickness and drug-loading manner of the silicone tubes on the drug release rate were examined using progestin, testosterone, estradiol as the delivery drugs. The results showed that the property of the drug was the crucial factor to the drug release rate. The sealing methods, length, thickness and drug status of the silicone tubes had significant effects on the drug release rate and the effects were closely related to the property of the drugs. In addition, our newly developed glass-silicone tube has larger drug deposition capability and smaller drug release area, offers an effective and convenient method for the sustained drug delivery with quick release traits in vivo.
