In vitro biologic evaluation on nano-hydroxyapatite/poly (L-lactic acid) biocomposites fabricated using in-situ growth method.
- Author:
Caiyun ZHANG
1
;
Qianfeng FENG
;
Tao ZHANG
;
Jin CHEN
;
Chuanhua LU
;
Hongfei WU
Author Information
1. Anhui Key Laboratory of Modernized Chinese Material, School of Pharmacy, Anhui Traditional Chinese Medical College, Hefei 230038, China. cyzhang@issp.ac.cn
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
Bone Substitutes;
chemical synthesis;
chemistry;
Durapatite;
chemical synthesis;
chemistry;
Lactic Acid;
chemistry;
Microscopy, Electron, Scanning;
Nanoparticles;
Polyesters;
chemical synthesis;
chemistry;
Polymers;
chemistry;
Porosity;
X-Ray Diffraction
- From:
Journal of Biomedical Engineering
2012;29(2):307-310
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this research was to estimate the bioactivity of nano-hydroxyapatite/poly (L-lactic acid) composites in simulated body fluid. In vitro test showed that the pH value of simulated body fluid (SBF) declined gradually and the existence of hydroxyapatite (HA) particles neutralized the acid degradation product of poly (L-lactic acid) (PLLA). Bone-like apatite deposited on the surface, and silkworm-like crystals and plate-like clusters appeared after soaking. At the same time, there were many honeycomb-like pores caused by nano-composite degraded. The results indicated that the hydroxyapatite/poly (L-lactic acid) nano-composites have good bioactivity and degradation characteristics.
