An analysis on biomedical effects of bipolar electric pulses at different central frequency.
- Author:
Yafang TAN
1
;
Hongchun YANG
;
Jun XU
;
Yi ZHANG
;
Minghe WU
;
Heng ZOU
Author Information
1. Physical Electronics College, University of Electronic Science and Technology of China, Chengdu 610054, China. yafang-tan@163.com
- Publication Type:Journal Article
- MeSH:
Apoptosis;
radiation effects;
B-Lymphocytes;
cytology;
radiation effects;
Cell Line, Tumor;
Cell Membrane;
physiology;
Electromagnetic Fields;
Electroporation;
methods;
Humans;
Jurkat Cells;
Nuclear Envelope;
pathology;
radiation effects
- From:
Journal of Biomedical Engineering
2012;29(3):438-442
- CountryChina
- Language:Chinese
-
Abstract:
Adopting the cell model of multilayer spherical symmetry and the circuit analysis, the present paper gives the calculated results of the voltages on each of several parts of malignant Tonsillar B-cells and Jurkat T lymphocytes when the first-order Gaussian pulses at different central frequency apposed on them. The relationship between the central frequency and the transmembrane voltages of plasma membrane is also given. The optimum frequency causing electroporation in nuclear envelope is given as well. The paper discusses the reasons of electroporation in membrane and DNA degradation in nuclear. The work provides a reference for usage of transient bipolar electric pulses in cancer treatment.
