Experimental study on animal with automatic drug injection based on predictive control for vascular interventional therapy.
- Author:
Haiyan TU
1
;
Zhirun YUAN
;
Xiaodong XIE
;
Chaohua WANG
;
Changwei ZHANG
;
Meixiong CHENG
;
Feng FAN
;
Ziyin ZHANG
;
Hongliang ZHANG
Author Information
1. College of Architecture & Environment, Sichuan University, Chengdu 610065, China.
- Publication Type:Journal Article
- MeSH:
Algorithms;
Animals;
Automation;
Dipyrone;
administration & dosage;
analogs & derivatives;
Forecasting;
Infusion Pumps;
Infusions, Intra-Arterial;
methods;
Pharmaceutical Preparations;
administration & dosage;
Swine
- From:
Journal of Biomedical Engineering
2012;29(3):460-464
- CountryChina
- Language:Chinese
-
Abstract:
This paper focuses on the animal experiment of automatic drug delivery based on predictive control for vascular interventional therapy. Improvement of drug delivery system based on predictive control used in simulated experiments was put forward after the presence of time varying parameters and the characteristics of individual differences of animal had been studied. The adaptability of time varying parameters and fault tolerance of the system were also enhanced. Different injection methods were tested on animals. It is proved that higher target blood concentration can be reached while injecting during diastolic than that while injecting during systolic or injecting at a constant speed within the whole cardiac cycle. The results also showed that the improved drug injection system based on predictive control which synchronizes with the cardiac cycle could be applied to clinical trials.
