Study on preparation and physicochemical properties of surface modified sintered bone.
- Author:
Jingfeng LI
1
;
Qixin ZHENG
;
Xiaodong GUO
Author Information
1. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biocompatible Materials;
chemical synthesis;
Biomimetic Materials;
chemical synthesis;
Bone Substitutes;
Bone and Bones;
chemistry;
drug effects;
Calcification, Physiologic;
physiology;
Cattle;
Chemical Phenomena;
Hydroxyapatites;
chemistry;
Porosity;
Surface Properties;
Tissue Engineering;
methods
- From:
Journal of Biomedical Engineering
2012;29(3):474-478
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study is to investigate a new method for preparing a biomimetic bone material-surface modified sintered bovine cancellous bone, and to improve its bioactivity as a tissue engineering bone. The prepared sintered bovine cancellous bones with the same size were randomly divided into two groups, immersing in 1 and 1. 5 times simulated body fluid (SBF), respectively. The three time periods of soak time were 7, 14, and 21 days. After sintered bone was dried, the surface morphology of sintered bone and surface mineralization composition were observed under scanning electron microscopy (SEM). By comparing the effect of surface modification of sintered bone materials, we chose the most ideal material and studied its pore size, the rate of the porosity, the compress and bend intensity. And then the material and the sintered bone material without surface modification were compared. The study indicated that sintered bone material immersed in SBF (1.5 times) for 14 days showed the best effect of surface modification, retaining the original physico-chemical properties of sintered bone.
