Effect of mucosal protective on the quality of gastric ulcer healing.
- Author:
Yun QIAN
1
;
Jian-Min SI
;
Jia-Guo WU
;
Shu-Jie CHEN
;
You-Fa ZHU
;
Ke-Ke SUN
;
Yan-Yong DENG
;
Kuang CHEN
;
Liang-Jing WANG
;
Wei-Li LIU
Author Information
- Publication Type:Journal Article
- MeSH: Acetic Acid; Animals; Anti-Ulcer Agents; therapeutic use; Diterpenes; therapeutic use; Drug Therapy, Combination; Gastric Mucosa; drug effects; metabolism; pathology; Male; Omeprazole; therapeutic use; Rats; Rats, Wistar; Receptor, Epidermal Growth Factor; biosynthesis; Secondary Prevention; Stomach Ulcer; chemically induced; drug therapy; pathology; Wound Healing; drug effects
- From: Journal of Zhejiang University. Medical sciences 2007;36(1):71-77
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the mucosal protective effect on the quality of gastric ulcer healing.
METHODSGastric ulcers were induced in male rats by serosal application of acetic acid. Rats were gavaged for 14 days with saline, omeprazole (OME), teprenone (TEP) and TEP plus OME starting 3 days after ulcer induction. Then the tissues and blood samples were obtained and measured.
RESULTThe lower ulcer index (UI) and increased ulcer inhibition rate were observed in OME and OME+TEP groups. In TEP and OME+TEP groups, restored mucosa thickness increased, cystically dilated glands decreased, microvessels in connective tissue increased, the secretion of mucus, hexosamine, PGE(2), bFGF were enhanced, the expression of EGFR was increased.
CONCLUSIONTEP can improve the quality of gastric ulcer healing, when combined with OME,the effect is more marked.
