Research advances in human mitochondrial DNA with aging and degenerative diseases.
- Author:
Dong-Dong TI
1
;
Xian-Ning ZHANG
Author Information
1. Department of Biochemistry and Genetics, Center for Genetic and Genomic Medicine, Institute of Cell Biology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Aging;
DNA, Mitochondrial;
genetics;
Genetic Therapy;
Humans;
Mitochondria;
genetics;
metabolism;
Mutation;
Neurodegenerative Diseases;
genetics;
therapy;
Reactive Oxygen Species;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2007;36(1):93-97
- CountryChina
- Language:Chinese
-
Abstract:
The human mitochondrial genome consists of approximate 1500 genes, among which 37 are encoded by the mitochondrial DNA (mtDNA) and the remainder encoded in the nuclear DNA (nDNA). The mitochondria produces large amount of the cellular reactive oxygen species (ROS). ROS induces the mutations of mtDNA and mtDNA, which are associated with a wide range of age-related diseases including neurodegenerative diseases, cardiomyopathy, diabetes and various cancers.
