Injection of saline into unilateral central piriform cortex inhibits amygdaloid-kindled seizures in rats.
- Author:
Yuan-Yuan ZHU
1
;
Zheng-Bing ZHU-GE
;
Shuang WANG
;
Li-Xia YANG
;
Zhong CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Amygdala; drug effects; physiopathology; Animals; Anticonvulsants; administration & dosage; metabolism; Cerebral Cortex; drug effects; physiopathology; Electric Stimulation; Epilepsy, Generalized; physiopathology; prevention & control; Kindling, Neurologic; drug effects; Male; Microinjections; Rats; Rats, Sprague-Dawley; Sodium Chloride; administration & dosage
- From: Journal of Zhejiang University. Medical sciences 2007;36(2):141-145
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of microinjection of saline into unilateral central piriform cortex (cPC) on the generalized seizures in amygdaloid-kindled rats.
METHODSDifferent volumes of saline were injected into the right or left cPC of amygdaloid-kindled rats, and its effect on generalized seizures was observed.
RESULTSaline injection at different volumes 0.1 microl, 0.25 microl and 1 microl) significantly decreased the incidence and duration of generalized seizures (P<0.05), the anticonvulsant effect lasted for up to 10 d. In addition, 10 min after ipsilateral injection of saline the generalized seizure thresholds were significantly increased; while this effect was observed 30 min later when contralateral injection was used.
CONCLUSIONUnilateral saline injection into cPC has a significant anticonvulsant effect, which might be used for treatment of human temporal lobe epilepsy in the future.
