Expression of PDGFR-alpha in gastrointestinal stromal tumor and its clinical significance.
- Author:
Song ZHENG
1
;
Li-rong CHEN
;
Hai-jun WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; biosynthesis; Female; Gastrointestinal Stromal Tumors; metabolism; pathology; Humans; Immunohistochemistry; Male; Middle Aged; Proto-Oncogene Proteins c-kit; biosynthesis; Receptor, Platelet-Derived Growth Factor alpha; biosynthesis
- From: Journal of Zhejiang University. Medical sciences 2007;36(3):280-284
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and clinical significance of platelet-derived growth factor receptor alpha (PDGFR-alpha) in gastrointestinal stromal tumor (GIST).
METHODSParaffin embedded tissue specimens from 119 GISTs were analyzed for PDGFR-alpha expression by immunohistochemical method, and specimens from non-GISTs were used as controls. Positive signals were shown in cytoplasma and cell membrane.
RESULTSOf 119 GISTs,78 (65.5%) were positive for PDGFR-alpha . The expression rate of PDGFR-alpha protein in very low risk, low risk, intermediate risk and high risk cases was 52.9 % (9/17), 71.0% ( 22/31), 67.9% (19/28) and 65.1% (28/43), respectively (P>0.05). PDGFR-alpha protein expression rate was significantly different between GISTs and non-GISTs (P<0.05).
CONCLUSIONPDGFR-alpha combined with CD117 can be used in diagnosis and differential diagnosis of GIST, but it may not be used as a prognostic index.
