Impact of intravenous nutrition on plasma free amino acid spectrum and immune function for patients with sepsis.
- Author:
Xue-ling FANG
1
;
Yun-tao ZHANG
;
Qiang FANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Amino Acids; blood; Complement C3; metabolism; Complement C4; metabolism; Female; Humans; Immunoglobulin M; blood; Male; Middle Aged; Parenteral Nutrition, Total; Sepsis; blood; immunology; therapy; Time Factors
- From: Journal of Zhejiang University. Medical sciences 2007;36(3):298-302
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the impact of intravenous nutrition on plasma free amino acid spectrum and immune function for patients with sepsis.
METHODSForty severe sepsis patients were divided into two groups: Group B (amino acids + glucose + fat emulsion) and Group A (glucose + fat emulsion), 20 healthy individuals were enrolled as control group. The concentration of free amino acid and immune globulin were determined after 3 days.
RESULTSIn Group A, the levels of valine, leucine, isoleucine, alanine, serine, glutamic acid, histidine, proline and glycine were decreased; while the levels of threonine, cysteine, the ratio of phenylalanine and tyrosine (Phe/Tyr) were higher than those in control group. Meanwhile, peripheral blood IgM, complement C3 and C4 were decreased. In group B, all amino acid levels were improved, but the level of alanine, serine, glutamic acid, histidine and proline still lower than those in control group. Similarly, the levels of IgM, complement C3 and C4 in group B were increased.
CONCLUSIONIntravenous nutrition can support the basal requirement of amino acid and improve the immune function of patients with sepsis.
