Progress in research on oocytes parthenogenetic activation.
- Author:
Mei-lian PENG
1
;
He-feng HUANG
;
Fan JIN
Author Information
1. The Affiliated Obstetrics and Gynecological Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.
- Publication Type:Journal Article
- MeSH:
Adenine;
analogs & derivatives;
pharmacology;
Animals;
Calcium;
metabolism;
Cycloheximide;
pharmacology;
Cytokines;
metabolism;
Female;
Humans;
Oocytes;
drug effects;
growth & development;
metabolism;
Parthenogenesis;
drug effects
- From:
Journal of Zhejiang University. Medical sciences
2007;36(3):307-312
- CountryChina
- Language:Chinese
-
Abstract:
Parthenogenetic activation is a procedure that an oocyte at meiosis II stage is activated into mitosis by some chemical or physical stimulation other than a sperm and the embryo is formed in the absence of any contribution from a male gamete. The activation of oocyte is the result of calcium ion oscillations and deactivation of some cytokines such as maturation promoting factor, mitogen-activated protein kinase and cytostatic factor. Parthenogenetic activation is artificially induced by various kinds of physical and/or chemical methods. The main activation method of human oocyte is chemical methods. The rates of activation and cleavage depend on the age, origin,and culture conditions of the oocyte.
