Autologous transplantation of peripheral blood stem cell in treatment of critical limb ischemia.
- Author:
Hong-kun ZHANG
1
;
Ming LI
;
Hua FENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Antigens, CD34; blood; Arterial Occlusive Diseases; surgery; Arteriosclerosis Obliterans; surgery; Female; Flow Cytometry; Granulocyte Colony-Stimulating Factor; pharmacology; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; cytology; drug effects; immunology; Humans; Leg; blood supply; Male; Middle Aged; Peripheral Blood Stem Cell Transplantation; methods; Treatment Outcome
- From: Journal of Zhejiang University. Medical sciences 2007;36(4):360-363
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo apply autologous transplantation of peripheral blood stem cells in the treatment of critical limb ischemia.
METHODSFifteen patients with critical lower limb ischemia were recruited in this study. After bone marrow mobilization, peripheral blood stem cells were collected using CS-3000 Plus device, and transplanted directly into the ischemic limb. In total 17 times of transplantation were performed.
RESULTSOne year after implanted peripheral blood stem cells, the pain scale decreased from 5 to 0, the ankle-brachial pressure index (ABI) increased from 0.30 to 0.46, the pain-free walking distance and maximal walking distance increased from 0.15 to 0.72 km and 0.96 to 2.13 km separately, from a total of 6 of 15 limb ulcers of transplanted patients 5 were healed after cell transplantation.
CONCLUSIONAutologous peripheral blood stem cell transplantation is able to induce functional angiogenesis in ischemic limb, which can significantly reduce rest pain, increase walk distance, and promote ulcer healing.
