Women with poor response to ovarian stimulation have increased follicular bone morphogenetic protein-15 levels.
- Author:
Yan-ting WU
1
;
Xiu-e LU
;
Ting-ting WANG
;
Rong-huan HE
;
Jian XU
;
He-feng HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Blotting, Western; Bone Morphogenetic Protein 15; Female; Follicle Stimulating Hormone; administration & dosage; Follicular Fluid; drug effects; metabolism; Gonadotropin-Releasing Hormone; administration & dosage; analogs & derivatives; Growth Differentiation Factor 9; Humans; Infertility, Female; metabolism; Intercellular Signaling Peptides and Proteins; biosynthesis; Ovary; drug effects; metabolism; Ovulation Induction
- From: Journal of Zhejiang University. Medical sciences 2007;36(5):439-442
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the levels of bone morphogenetic protein-15 (BMP-15) in human follicular fluid (FF) and its association with response to ovarian stimulation.
METHODSWestern blotting was performed to determine the levels of BMP-15 in FF obtained from follicle aspirates in 70 patients undergoing IVF treatment. According to the response to ovarian stimulation the patients were divided into poor responder group and normal responder group.
RESULTBMP-15 levels in FF of poor responders were significantly higher than those in normal responders (1.01 +/- 0.34 vs 0.77 +/- 0.24, P<0.01).
CONCLUSIONIncreased levels of BMP-15 in FF may be associated with poor response to ovarian stimulation.
