Pharmacokinetics of breviscapine liposomes following intravenous injection in Beagle dogs.
- Author:
Wen-Li LO
1
;
Jian-Xin GUO
;
Qi-Neng PING
;
Jin LI
;
Chu-Wei ZHAO
;
Lan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apigenin; blood; Area Under Curve; Brain; metabolism; Cross-Over Studies; Delayed-Action Preparations; Dogs; Drug Compounding; Drug Stability; Erigeron; chemistry; Female; Flavonoids; administration & dosage; isolation & purification; pharmacokinetics; Glucuronates; blood; Injections, Intravenous; Liposomes; Male; Plants, Medicinal; chemistry
- From: Acta Pharmaceutica Sinica 2006;41(1):24-29
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo prepare the breviscapine liposomes and study the pharmacokinetics of breviscapine liposomes in Beagle dogs.
METHODSThe cross-over design (two periods) was employed. Six Beagle dogs were administrated a single intravenous dosage of 28 mg of breviscapine liposomes and reference preparation, respectively, scutellarin in plasma of 6 dogs at different sampling time was determined by RP-HPLC. The pharmacokinetic parameters were calculated by 3P97 program and compared by statistic analysis.
RESULTSThe mean concentration-time curves of breviscapine liposomes and reference preparation were both fitted to two-compartment model with the main pharmacokinetic parameters as follows: T 1/2 alpha were (4.4 +/- 0.7) min and (1.8 +/- 1.3) min respectively; T 1/2 beta were (55 +/- 27) min and (28 +/- 23) min respectively; V(c) were (1 580 +/- 265) mL and (2 460 +/- 2 200) mL respectively; CL(s) were (88 +/- 10) mL x min(-1) and (324 +/- 69) mL x min(-1) respectively; and AUC(0-720) were (363 +/- 42) microg x min x mL(-1) and (102 +/- 19) microg x min x mL(-1) respectively. The T 1/2 alpha, CL(s) and AUC(0-720) of breviscapine liposomes all had significant difference from those of reference preparation, after the data were examined by a one-way analysis of variance (ANOVA).
CONCLUSIONCompared with the reference preparation, breviscapine liposomes had a much more higher concentration in plasma and contained characteristic of sustained-release, which ameliorated the pharmacokinetic properties of scutellarin.
