Preparation of gelatin nanogel modified with fluoride anion and its ultrasonic triggered release characteristics.
- Author:
Dao-cheng WU
1
;
Ming-xi WAN
;
Hong WU
Author Information
- Publication Type:Journal Article
- MeSH: Doxorubicin; administration & dosage; Drug Carriers; Drug Delivery Systems; Fluorides; Gelatin; Nanoparticles; Particle Size; Polyethylene Glycols; chemistry; Polyethyleneimine; chemistry; Ultrasonics
- From: Acta Pharmaceutica Sinica 2006;41(4):313-317
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the preparation, shape and ultrasound triggered release characteristics of gelatin nanogel modified with fluoride anion.
METHODSAdriamycin gelatin nanogel modified with fluoride anion (ADM-FMNG) was prepared by co-precipitation with fluoride anion. The content and encapsulation rate of adriamycin were measured by HPLC method. The size and shape of ADM-FMNG were determined by electron microscope. The size and distribution of ADM-FDNG before and after sonication were measured by laser size analysis device.
RESULTSThe average diameter of ADM-FMNG was (46 +/- 12) nm. Adriamycin encapsulated rate and loading were 87.2% and 0.091 g x L(-1), respectively. 48.5% of adriamycin was released within 50 h while in vitro at 37 degrees C. Under the action of ultrasound that has the frequency of 20 kHz, 0.4 W x cm(-2) of power density and 7-8 min duration, 51. 5% of adriamycin in ADM-FMNG was released that was significantly higher than control group, the size of ADM-FMNG was changed from (46 +/- 12) nm to (1,212 +/- 35) nm and restored after ultrasound stopped for 3-4 min.
CONCLUSIONADM-FDNG system has the sensitive ultrasound triggered release characteristics.
