Spontaneous Apoptosis and Metastasis in Squamous Cell Carcinoma of the Lung.
- Author:
Yoon Kyeong OH
1
;
Keun Hong KEE
Author Information
1. Department of Therapeutic Radiology, Chosun University Medical College, Korea.
- Publication Type:Original Article
- Keywords:
Lung cancer;
Spontaneous apoptosis;
Metastasis
- MeSH:
Apoptosis*;
Carcinoma, Squamous Cell*;
Coloring Agents;
Diagnosis;
Drug Therapy;
Humans;
Lung Neoplasms;
Lung*;
Multivariate Analysis;
Neoplasm Metastasis*
- From:The Journal of the Korean Society for Therapeutic Radiology and Oncology
1999;17(3):203-208
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate whether spontaneous apoptosis has prognostic value among patients with squamous cell carcinoma of lung. MATERIALS AND METHODS: Material from 19 patients who received thoracic irradiation between 1990 and 1994 was analyzed. Their stages were II (1), IIIa (8), IIIb (5), and IV (5). Patients were observed from 5 to 67 months (median : 17 months). The spontaneous apoptosis index (AI) and p53 mutation were measured by immunohistochemical stains. RESULTS: AI was found to range from 0 to 1% (median 0.4%). Patients with low AI (AI< or =median) had a much higher distant metastasis rate at diagnosis than patients with high AI. By analysis of prognostic factors for survival, M stage was significant in univariate analysis. AI, chemotherapy, M stage, T stage, and stage were significant in multivariate analysis. The correlation between the AI and p53 mutation was not seen. CONCLUSION: AI was related with distant metastasis at diagnosis and not with p53 mutation. Also low AI group tended to have shorter survival time than high AI group.
