Treatment of superficial infantile hemangiomas with topical propranolol.
- Author:
Jing-Ning NIU
1
;
Guang-Qi XU
;
Ren-Rong LÜ
;
Ran HUO
Author Information
- Publication Type:Journal Article
- MeSH: Female; Hemangioma; drug therapy; Humans; Infant; Male; Ointments; Propranolol; administration & dosage; therapeutic use; Skin Neoplasms; drug therapy; Treatment Outcome
- From: Chinese Journal of Plastic Surgery 2013;29(2):100-103
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy and safety of 1% propranolol ointment in the treatment of superficial infantile hemangiomas (IHs).
METHODSA retrospective chart review was performed on 49 children (34 female and 15 male) with a median age of 4.1 months (range, 1-10 months). A total of 58 superficial IHs were treated with 1% propranolol ointment. Topical propranolol was applied three times daily for a mean duration of 21.1 weeks (range, 5-59 weeks). Changes in the size, texture, and color of the tumor were monitored and recorded at regular intervals. The treatment response was evaluated using a 3-point scale system: good, partial, and no response. Adverse effects after medication were evaluated and managed accordingly.
RESULTSOf the 49 cases, 26 (53.1%) demonstrated good response, 17 (34.7%) showed a partial response, and 6 (12.2%) had no response. The total effective rate was 87.8% . No systemic complication was observed in any of the patients.
CONCLUSIONSTopical therapy with 1% propranolol ointment may be a safe and effective method for the treatment of superficial IHs and can be used as an adjuvant treatment measure during the wait-and-see period.
