The significance of beta-receptor expression in infantile hemangiomas.
- Author:
Jing LI
1
;
Xiao-Dan LI
;
Yu CAI
;
Jia-Feng LIU
;
Hui LIU
;
Zhe-Yuan ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Female; Hemangioma; metabolism; Humans; Immunohistochemistry; Infant; Male; Receptors, Adrenergic, beta; metabolism
- From: Chinese Journal of Plastic Surgery 2013;29(4):290-293
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and significance of beta-receptor ( p-R) in infantile hemangioma.
METHODSThe expression of beta-R was detected by immunohistochemistry in infantile hemangioma (40 cases), venous malformation (20 cases) and normal skin (10 cases).
RESULTSThe positive expression rate of beta2-R was 70% (28/40) in infantile hemangioma, while no expression of beta2-R in venous malformation and normal skin. Among 28 cases with positive expression of beta2-R, 24 cases were in proliferative phase. The positive expression of beta2-R in infantile hemangioma was significantly higher than that in venous malformation and normal skin tissue. The positive expression of beta2-R in the proliferative hemangioma and non-proliferative hemangioma was also significantly different (P < 0.05).
CONCLUSIONSbeta2-R is specifically expressed in infantile hemangioma, especially in proliferative hemangioma.
