Are the Clinical outcomes of Neonates and Infants Under 2 Months Old with Urinary Tract Infections Similar to those in Infants 2 to 12 Months Old?.
10.3339/chikd.2015.19.2.136
- Author:
Jee Hoo LEE
1
;
Hyunwook LIM
;
Kyungju KIM
;
Hyung Eun YIM
;
Kee Hwan YOO
Author Information
1. Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea. guroped@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Urinary tract infection;
Young infant;
Hydronephrosis
- MeSH:
C-Reactive Protein;
Escherichia coli;
Fever;
Humans;
Hydronephrosis;
Infant*;
Infant, Newborn*;
Leukocytes;
Pediatrics;
Pyelonephritis;
Recurrence;
Urinary Tract Infections*;
Urinary Tract*;
Vesico-Ureteral Reflux
- From:Childhood Kidney Diseases
2015;19(2):136-142
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Although the American Academy of Pediatrics provides clinical guidelines for urinary tract infection (UTI) infants, guidelines are not appropriate for neonates and infants less than 2 months of age due to insufficient data. The aim of this study was to evaluate the characteristics of neonates and young infants less than 2 months old (group 1) with UTI compared to older infants from 2 to 12 months old (group 2). METHODS: We reviewed UTI patients aged 0 to 12 months admitted to the pediatric department in the last 5 years. Clinical characteristics such as age, sex, fever duration, recurrence, progression to acute pyelonephritis (APN), malformations like hydronephrosis and vesicoureteral reflux (VUR), and laboratory results were compared between group 1 and group 2. RESULTS: 615 patients were included in this study. Group 1 had 94 cases and group 2 had 521 cases. Escherichia coli was the most commonly isolated pathogen in urine cultures. Fever duration was shorter in group 1 (vs.) 2 (1.91+/-1.43 days vs. 3.42+/-2.40 days, P<0.05). As compared to group 2, group 1 had a higher proportion of patients with antenatal hydronephrosis and hydronephrosis found after admission (10.6% vs. 3.6% and 75.5% vs. 55.9%, P<0.05). There were differences between two groups in white blood cell (WBC) count (Group 1: 13,694+/-5,315/microL, Group 2: 15,271+/-6,130/microL, P<0.05) and C-reactive protein (Group 1: 32.02+/-35.17 mg/L, Group 2: 46.51+/-46.63 mg/L, P<0.05). CONCLUSION: Compared to older infants, UTI in neonates and young infants shows milder clinical manifestations except higher rates of hydronephrosis but outcome is alike.
