A case control study on the impact of CYP450 MSPI and GST-M1 polymorphisms on the risk of lung cancer.
- Author:
Bao-guo WANG
1
;
Si-dong CHEN
;
Wei-ping ZHOU
;
Mian ZENG
;
Zhi-biao LI
;
Xu-ling CAI
;
De-quan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Case-Control Studies; Cytochrome P-450 CYP1A1; genetics; Female; Genotype; Glutathione Transferase; genetics; Humans; Lung Neoplasms; etiology; genetics; Male; Middle Aged; Polymorphism, Genetic; Risk; Smoking; adverse effects
- From: Chinese Journal of Oncology 2004;26(2):93-97
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the correlation of polymorphisms of CYP1A1 MSPI and glutathiones S-transferase (GST-M1) independently and in combination with the risk of lung cancer.
METHODSA case control study which included 91 cases of lung cancer and 138 controls collected from the First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou Tumor Hospital and The Red Cross Hospital of Guangzhou or conmunity area. All subjects were investigated with a uniform questionnaire. Blood samples were collected from all cases and controls for detecting CYP1A1 MSPI and GST-M1 polymorphisms which were analyzed by PCR and RFLP.
RESULTSIt showed that there was no significant difference in frequencies of this genotypes of CYP1A1 MSPI between the two groups. The frequency of GST-M1 null (0/0) genotype was higher in the case group than in the control group, with an OR of 1.38 (95% CI 0.81 - 2.38), but there was no statistical significance. However, combination of several genotypes was strongly associated with lung cancer. There was a synergistic interaction between the m2m2 genotype of CYP1A1 MSPI and GST-M1 (0/0) genotype, with an OR of 2.47 (95% CI 1.03 - 5.90).
CONCLUSIONThe combination of two genetic polymorphisms significantly increases the risk of lung cancer.
