The mRNA expression of platelet-derived endothelial cell growth factor of bladder transitional cell carcinoma and its relation to invasiveness.
- Author:
Gang LI
1
;
Yuan-fang ZHANG
;
Qiang DING
;
Duan-gai WEN
;
Chun-yin YAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Transitional Cell; metabolism; pathology; Cell Differentiation; Female; Humans; Male; Middle Aged; Neoplasm Invasiveness; RNA, Messenger; analysis; Thymidine Phosphorylase; genetics; Urinary Bladder Neoplasms; metabolism; pathology
- From: Chinese Journal of Oncology 2004;26(1):30-32
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between mRNA expression of platelet-derived endothelial cell growth factor (PD-ECGF) and invasion of bladder transitional cell carcinoma (BTCC).
METHODSThe mRNA expression of PD-ECGF in BTCC was detected by RT-PCR. The target PCR bands were analyzed by NIH Image 1.62 software.
RESULTSThe mRNA level of PD-ECGF in BTCC was 3.86 times as high as that of normal bladder mucosa (t = 2.36, P < 0.05). The expression level of stage Ta, T1 and T2-4 tumor was 1.33, 4.02 and 7.59 times as high as that of normal bladder mucosa, respectively. That of Grade 3 tumor was 2.27 times as high as that of Grade 1 - 2 tumor (t = 3.52, P < 0.01).
CONCLUSIONThe mRNA expression of PD-ECGF was positively correlated with the invasiveness and grade of BTCC. The results suggest that the mRNA level of PD-ECGF might be used as an indicator of tumor progression and a guide for clinical treatment of bladder transitional cell carcinoma.
